Casting for the Cure

Marijuana is among the most frequently used illicit drugs by women during their childbearing years and there is growing concern that marijuana abuse during pregnancy, either alone or in combination with other drugs, may have serious effects on fetal brain development. There is strong evidence that THC, the main psychoactive component of marijuana, crosses the placenta, that maternal marijuana abuse results in intrauterine growth retardation and that infants exposed to marijuana exhibit a temporary syndrome that includes lethargy and decreased muscle tone. Fetal exposure to THC can also result in attention deficits, learning disabilities and behavioral problems. A new study using rats found that THC combined with mildly intoxicating doses of alcohol induced widespread nerve cell death in the brain. The study is published in the Annals of Neurology, the official journal of the American Neurological Association.

Led by Henrik Hansen and Chrysanthy Ikonomidou, at the Neuroscience Research Center of the Humboldt University in Berlin and the Department of Pediatric Neurology, University of Technology Dresden, Germany, researchers administered THC, a synthetic form of THC, ethanol, MK-801 (an anticonvulsant) and phenobarbital by injection to rats between 1 and 14 days old. A previous study by the same group had shown that ethanol and drugs such as sedatives, anesthetics and anticonvulsants triggered widespread nerve cell death in the developing brain of immature rodents; the current study was conducted to determine if cannabinoids had the same effect.

lanjut →

Keeping middle schoolers from alcohol is a tougher task in the inner city than in rural areas, even for experts armed with the best prevention programs, a new University of Florida study shows.

A three-year, three-pronged prevention program did little to keep Chicago middle schoolers from drinking or using drugs, despite its prior success in rural Minnesota, where the program reduced alcohol use 20 to 30 percent, UF and University of Minnesota researchers recently reported in the online edition of the journal Addiction.

“The intervention found to be effective in rural areas was not effective here, which really surprised us,” said Kelli A. Komro, a UF associate professor of epidemiology in the UF College of Medicine and the study’s lead author. “This is an important finding to realize this program was not enough. The bottom line is this: Low-income children in urban areas need more, long-term intensive efforts.”

lanjut →