Casting for the Cure

We’ve had it drummed into us that smoking and drinking when pregnant can harm the baby, but new research published in The Journal of Physiology suggests that poor diet can also cause long-lasting, irreversible damage in offspring; from heart disease to diabetes.

To establish the dangers of a junk food diet, researchers Stéphanie Bayol and Neil Stickland at the Royal Veterinary College, London, fed female rats a diet of crisps, cheese, muffins and other processed foods throughout pregnancy and lactation.

The offspring, who were overweight at birth, were born with a taste for junk-food themselves. But even when fed a healthy diet, the junk-food babies had a host of medical problems that lasted beyond adolescence.

Bayol noted that the rats had raised cholesterol and triglyceride levels - both associated with heart disease and that insulin and glucose levels were also unusually high, known to be a cause of type-2 diabetes.

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The great innovators of our time are said to be the titans of technology - the inventors of the microchip, the founders of Microsoft, the guys behind Google. But far from Silicon Valley another great thinker and innovator is changing the world with far less fanfare. His name is Dr. Paul Farmer.

As Byron Pitts reports, more than 20 years ago Dr. Farmer and a few other great minds created a charity called “Partners In Health.” In the years since, they revolutionized the delivery of healthcare worldwide, saving millions of lives in places where no one thought there was any reason for hope.

“The idea that because you’re born in Haiti you could die having a child. The idea that because you’re born in you know Malawi your children may go to bed hungry. We want to take some of the chance out of that,” Farmer tells Pitts.

Farmer invited 60 Minutes to central Haiti, where he discovered his life’s work 25 years ago. The invitation meant a three-hour, jaw clenching, teeth rattling ride on an unpaved road from the capital city to the hospital.

If the ride doesn’t break your back, what you see when you arrive will break your heart: the squatter settlement of Cange is one of the poorest parts of the poorest country in the Western Hemisphere.

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A cognitive behavioral intervention for insomnia delivered via the Internet can significantly improve insomnia in adults, according to a research abstract presented at SLEEP 2008, the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS).

The study, authored by Lee Ritterband, PhD, of the University of Virginia, focused on 44 participants (mostly female) with an average age of 45 years. The participants were randomly selected to either the cognitive behavioral intervention for insomnia via the Internet or a wait list control. Measures of sleep, mood, cost, and cognitive functioning were collected at pre- and post-treatment, while additional measures of sleep were collected throughout treatment.

According to the results, sleep improved significantly for those who received a cognitive behavioral intervention for insomnia via the Internet over the six-week intervention, whereas control participants showed no change during the treatment period. Sleep efficiency also significantly improved for the experimental group from pre- to post- assessment, with no change for the controls. The experimental group increased total sleep time by 80 minutes and the control group increased by nine minutes.

“We believe these types of Web-based treatment programs have the potential to impact countless individuals around the world,” said Dr. Ritterband. “Specifically related to insomnia, the availability of non-pharmacological help is significantly lacking. The Internet has already become a critical source of health-care and medical information. The Internet may prove an effective tool to more broadly disseminate cognitive behavioral therapy for insomnia.”

Insomnia is a classification of sleep disorders in which a person has trouble falling asleep, staying asleep or waking up too early. It is the most commonly reported sleep disorder. About 30 percent of adults have symptoms of insomnia. It is more common among elderly people and women.

Cognitive behavioral therapy (CBT) helps you change actions or thoughts that hurt your ability to sleep well. It helps you develop habits that promote a healthy pattern of sleep. CBT is most often used for people who suffer from insomnia.

The American Academy of Sleep Medicine (AASM) offers the following tips on how to get a good night’s sleep:

• Follow a consistent bedtime routine.
• Establish a relaxing setting at bedtime.
• Get a full night’s sleep every night.
• Avoid foods or drinks that contain caffeine, as well as any medicine that has a stimulant, prior to bedtime.
• Do not bring your worries to bed with you.
• Do not go to bed hungry, but don’t eat a big meal before bedtime either.
• Avoid any rigorous exercise within six hours of your bedtime.
• Make your bedroom quiet, dark and a little bit cool.
• Get up at the same time every morning.

Those who suspect that they might be suffering from insomnia, or another sleep disorder, are encouraged to consult with their primary care physician or a sleep specialist.

A group of Swiss investigators has reported on a new conceptualization of the effects of behavioral conditioning in allergic rhinitis in the fourth 2008 issue of Psychotherapy and Psychosomatics.

Allergic symptoms can be induced by behavioral conditioning. However, the conditionability of antiallergic effects has not yet been studied. Thus, in this study the Authors investigated whether the effects of a histamine 1 (H1) receptor antagonist are inducible in patients suffering from house-dust mite allergy using a behavioral conditioning procedure. During the association phase, 30 patients with allergic house-dust mite rhinitis received a novel-tasting drink once daily, followed by a standard dose of the H1 receptor antagonist, desloratadine, on 5 consecutive days. After 9 days of drug washout, the evocation trial commenced: 10 patients received water together with an identically looking placebo pill (water group), 11 patients were re-exposed to the novel-tasting drink and received a placebo pill [conditioned stimulus (CS); CS group] and 9 patients received water and desloratadine (drug group). During the association phase, desloratadine treatment decreased the subjective total symptom scores, attenuated the effects of the skin prick test for histamine and reduced basophil activation ex vivo in all groups. During the evocation trial, the water group, in which subjects were not re-exposed to the gustatory stimulus, showed a reduction in subjective total symptom scores and skin prick test results, but no inhibition of basophil activation. In contrast, re-exposure to the novel-tasting drink decreased basophil activation, the skin prick test result and the subjective symptom score in the CS group to a degree that was similar to the effects of desloratadine in the drug group.

Food may not be the major cause of hyperactivity in children. Genetics, brain function and parental actions such as smoking may be just as important.

A review of scientific evidence found only a minority of children were actually affected by what they eat. A combination of food, genetics and environmental toxins are more likely to be involved, with no single factor to blame.

Foods which might affect behaviour, in particular table sugar were studied. No adverse effects were seen in children who had a sugary drink versus a drink with artificial sweetener. Parents often believe their children’s diet is making them hyperactive and think changes in the food provided is the answer to the problem. However changing your child’s diet is not likely to settle their over active behaviour.

ADHD (attention deficit/hyperactivity disorder) has a strong genetic link, with half the children born of parents with diagnosed ADHD likely to develop the disorder themselves. Chemical imbalances in the brain are also involved and studies have found that children with the condition have on average 4% smaller brains. Genes may interact with environmental toxins such as alcohol in the womb, lead, and parental smoking to cause later problems with attention span.

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Video games that energize players and induce a positive mood could also enhance creativity, according to media researchers. However, the study also finds that players who were not highly energized and had a negative mood, registered the highest creativity.

“You need defocused attention for being creative,” said S. Shyam Sundar, professor of film, video and media studies at Penn State. “When you have low arousal and are negative, you tend to focus on detail and become more analytical.”

Sundar and Elizabeth Hutton, a Penn State graduate student, are trying to understand the value of video games as a vehicle for sparking positive social traits, such as creativity. Fun and games aside, video games are viewed as a serious communication technology. Schools, corporations and even the government are increasingly employing it as a tool in enhancing learning and decision-making.

“Video games are not just for entertainment alone,” says Sundar. “We are trying to figure out how they can aid in education as well.”

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High levels of low-density lipoproteins (LDL), the “bad” cholesterol, have long been associated with memory problems experienced by the elderly but new research on the effects of the high-density lipoproteins (HDL), shows that high levels of the “good” cholesterol in middle age are beneficial in maintaining good memory well into the twilight years and may reduce the chances of developing age-related dementia.

HDL and memory lossThe British Whitehall II study, a long-term study of the health of more than 10,000 British civil servants, isolated 3,673 study participants, of whom 26.8% were women, during phases 5 and 7 of the study, which began in 1985, to analyze the effect of HDL on memory function as the study participants reached middle age.

The presence of memory impairment in middle age is a strong indicator of dementia developing later in life. People who are 65 years and older are the fastest growing age group in the world’s industrialized countries and are at the most risk of developing dementia.

For the sake of the study, a low level of HDL was considered to be 40 mg/dL while 60 mg/dL or higher was considered high. Performance on memory tests and blood-fat content were compared from phase 5 of the study, conducted in 1995, when study participants were of the average age of 55, to the same study participants when their average age was 61, during phase 7 of the study in 2002.

The memory tests involved a participant’s ability to recall 20 short words read to them one word at a time at an interval of two seconds per word. After hearing all 20 words, consisting of only one or two syllables, the participant was given two minutes to write down as many words as he or she could remember.

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There may be constituents in wine that protect against dementia. This is shown in research from the Sahlgrenska Academy at University of Gothenburg in Sweden.

The findings are based on 1,458 women who were included in the so-called Population Study of Women from 1968. When they were examined by physicians they were asked to report how often they drank wine, beer, and liquor by selecting from seven categories on a scale from ‘never’ to ‘daily.’ The researchers know nothing about how much they drank on each occasion, or how correct the estimates were. For each beverage the women reported having drunk more than once a month, they were classified as a consumer of that particular beverage.

Thirty-four years after the first study, 162 women had been diagnosed with dementia. The results show that among those women who reported that they drank wine a considerably lower proportion suffered from dementia, whereas this correlation was not found among those who had reported that they regularly drank beer or liquor.

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Marijuana is among the most frequently used illicit drugs by women during their childbearing years and there is growing concern that marijuana abuse during pregnancy, either alone or in combination with other drugs, may have serious effects on fetal brain development. There is strong evidence that THC, the main psychoactive component of marijuana, crosses the placenta, that maternal marijuana abuse results in intrauterine growth retardation and that infants exposed to marijuana exhibit a temporary syndrome that includes lethargy and decreased muscle tone. Fetal exposure to THC can also result in attention deficits, learning disabilities and behavioral problems. A new study using rats found that THC combined with mildly intoxicating doses of alcohol induced widespread nerve cell death in the brain. The study is published in the Annals of Neurology, the official journal of the American Neurological Association.

Led by Henrik Hansen and Chrysanthy Ikonomidou, at the Neuroscience Research Center of the Humboldt University in Berlin and the Department of Pediatric Neurology, University of Technology Dresden, Germany, researchers administered THC, a synthetic form of THC, ethanol, MK-801 (an anticonvulsant) and phenobarbital by injection to rats between 1 and 14 days old. A previous study by the same group had shown that ethanol and drugs such as sedatives, anesthetics and anticonvulsants triggered widespread nerve cell death in the developing brain of immature rodents; the current study was conducted to determine if cannabinoids had the same effect.

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Male infants in developed nations are more likely to die than female infants, a fact that is partially responsible for men’s shorter lifespans, reveals a new study by researchers from University of Pennsylvania and University of Southern California.

The paper, which will be published online in the Monday, March 24 edition of the Proceedings of the National Academy of Sciences, analyzes 15 countries spanning three continents and hundreds of years. It finds that the gender gap in infant mortality was as high as 30 percent at its peak around 1970.

The disparity has narrowed in recent decades due to medical advancements that have helped more baby boys survive, specifically, caesarean sections and the spread of intensive care units for premature babies, the study found.

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